Recent advancements in high-resolution mass spectrometers (HR-MS) have expanded their potential applications to include stable isotope ratio analysis. Traditionally, isotope ratio measurements have been conducted using isotope ratio mass spectrometry (IRMS). However, HR-MS now enables compound-specific isotope ratio measurements, taking advantage of its high resolution and mass accuracy.

In our laboratory, we are developing quantitative methods for determining carbon and nitrogen stable isotope ratios in organic compounds using an Orbitrap-type HR-MS. By analyzing precise mass differences using certified reference standards and optimizing both internal standard and external calibration methods, we aim to establish a rapid, non-destructive alternative to conventional techniques.

Currently, our focus is on developing isotope analysis methods for environmental contaminants such as PFAS (per- and polyfluoroalkyl substances) and pesticides. These methods are intended for applications such as source attribution and understanding environmental fate. We also collaborate with engineers from Thermo Fisher Scientific and other partners to advance international capabilities in isotope analysis.

Our long-term goal is to promote the application of HR-MS-based stable isotope analysis across a wide range of fields, including food science, environmental studies, and life sciences.